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Edison P, Femminella GD, Ritchie CW, Holmes C, Walker Z, Ridha BH, et al

This landmark study remains one of the strongest demonstrations of a neuropeptide's sleep-promoting activity in preclinical models Eur J Neurosci (2007) -- further characterization of cortistatin's sleep neurobiology, confirming the initial findings Anti-inflammatory studies -- cortistatin has demonstrated potent anti-inflammatory effects in multiple preclinical models (IBD: PNAS 2006, sepsis: J Leukoc Biol 2006, arthritis, atherosclerosis)

doi: 10.1038/nature25986 79 WeissJMDaviesLCKarwanMIlevaLOzakiMKChengRYet al